NLRP6 deficiency inhibits neuroinflammation and ameliorates brain injury in ischemic stroke by blocking NLRs inflammasomes activation through proteasomal degradation of pro-caspase-1

Innate inflammation is crucial for ischemic stroke development. NLRP6, a nucleotide-binding and oligomerization domain-like receptors (NLRs) family member, regulates innate inflammation. Whether NLRP6 regulates neurological damage and neuroinflammation during ischemic stroke remains unclear. We repo...

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Detalhes bibliográficos

Principais autores:	Qi He, Changchang Meng, Mengjie Jia, Junyi Tan, Keli Huang, Hui Gan, Lingyu Li, Jing Zhao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-03-01
coleção:	Neurobiology of Disease
Assuntos:	Ischemic stroke Innate inflammation Inflammasome NLRP6 Pro-caspase-1 NLRP3
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996124000330
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