The development and survival but not function of follicular B cells is dependent on IL-7Rα Tyr449 signaling.
IL-7 is a critical cytokine for lymphocyte development. Recent work has highlighted critical roles for IL-7 signaling in mature T cell homeostasis and function, but its role in B cells is less well characterized. Using a knock-in mouse possessing a Tyr to Phe mutation at position 449 (IL-7Rα(449F/44...
Guardat en:
| Autors principals: | , , , , , |
|---|---|
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science (PLoS)
2014-01-01
|
| Col·lecció: | PLoS ONE |
| Accés en línia: | http://europepmc.org/articles/PMC3923819?pdf=render |
| Etiquetes: |
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|