A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for in vivo therapeutic screening

Mutations in the superoxide dismutase gene (SOD1) are one cause of familial amyotrophic lateral sclerosis [ALS; also known as motor neuron disease (MND)] in humans. ALS is a relentlessly progressive neurodegenerative disease and, to date, there are no neuroprotective therapies with significant impac...

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Автори:	Marc M. J. Da Costa, Claire E. Allen, Adrian Higginbottom, Tennore Ramesh, Pamela J. Shaw, Christopher J. McDermott
Формат:	Artigo
Мова:	Inglês
Опубліковано:	The Company of Biologists 2014-01-01
Серія:	Disease Models & Mechanisms
Предмети:	MND ALS SOD1 Zebrafish
Онлайн доступ:	http://dmm.biologists.org/content/7/1/73
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