A Novel P-III Metalloproteinase from <i>Bothrops barnetti</i> Venom Degrades Extracellular Matrix Proteins, Inhibits Platelet Aggregation, and Disrupts Endothelial Cell Adhesion via α5β1 Integrin Receptors to Arginine–Glycine–Aspartic Acid (RGD)-Containing Molecules

Viperid snake venoms are notably abundant in metalloproteinases (proteins) (SVMPs), which are primarily responsible for inducing hemorrhage and disrupting the hemostatic process and tissue integrity in envenomed victims. In this study, barnettlysin-III (Bar-III), a hemorrhagic P-III SVMP, was purifi...

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Detalhes bibliográficos

Principais autores:	Pedro Henrique de Caires Schluga, Debora Larangote, Ana Maria de Melo, Guilherme Kamienski Lobermayer, Daniel Torrejón, Luciana Souza de Oliveira, Valeria Gonçalves Alvarenga, Dan Erick Vivas-Ruiz, Silvio Sanches Veiga, Eladio Flores Sanchez, Luiza Helena Gremski
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-11-01
Colecção:	Toxins
Assuntos:	snake venom metalloproteinase disintegrin animal venoms <i>Bothrops barnetti</i>
Acesso em linha:	https://www.mdpi.com/2072-6651/16/11/486
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