Lactate Dehydrogenase C4 Accelerates Triple‐Negative Breast Cancer Progression by Promoting Acetyl‐CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation

Abstract Lactate‐induced protein lysine (K) lactylation is inherently connected to cellular metabolism and is implicated in oncogenesis. As a crucial glycolytic enzyme in lactate metabolism, lactate dehydrogenase C4 (LDHC4) has undefined yet potentially significant biological functions and mechanist...

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Główni autorzy:	Zhaolei Cui, Chaoqiang Zheng, Yingying Lin, Zhenzhou Xiao, Yanhong Li, Wei Peng, Shijie He, Anyang Li, Xiufeng Wu, Yan Chen, Yang Sun
Format:	Artigo
Język:	Inglês
Wydane:	Wiley 2025-10-01
Seria:	Advanced Science
Hasła przedmiotowe:	acetyl‐CoA acyltransferase 2 free fatty acids lactylation lactate dehydrogenase C4 triple‐negative breast cancer
Dostęp online:	https://doi.org/10.1002/advs.202511849
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