C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease.

The pan lymphocyte marker CD45 exists in various isoforms arising from alternative splicing of the exons 4, 5 and 6. While naïve T cells express CD45RA translated from an mRNA containing exon 4, exons 4-6 are spliced out to encode the shorter CD45R0 in antigen-experienced effector/memory T cells. Th...

Полное описание

Библиографические подробности

Главные авторы:	Johannes Landskron, Sigrid M Kraggerud, Elisabeth Wik, Anne Dørum, Merete Bjørnslett, Espen Melum, Øystein Helland, Line Bjørge, Ragnhild A Lothe, Helga B Salvesen, Kjetil Taskén
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2017-01-01
Серии:	PLoS ONE
Online-ссылка:	https://doi.org/10.1371/journal.pone.0182030
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