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Schwann cells modulate nociception in neurofibromatosis 1

Pain of unknown etiology is frequent in individuals with the tumor predisposition syndrome neurofibromatosis 1 (NF1), even when tumors are absent. Nerve Schwann cells (SCs) were recently shown to play roles in nociceptive processing, and we find that chemogenetic activation of SCs is sufficient to i...

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Furkejuvvon:
Váldodahkkit: Namrata G.R. Raut, Laura A. Maile, Leila M. Oswalt, Irati Mitxelena, Aaditya Adlakha, Kourtney L. Sprague, Ashley R. Rupert, Lane Bokros, Megan C. Hofmann, Jennifer Patritti-Cram, Tilat A. Rizvi, Luis F. Queme, Kwangmin Choi, Nancy Ratner, Michael P. Jankowski
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: American Society for Clinical investigation 2024-01-01
Ráidu:JCI Insight
Fáttát:
Neuroscience
Liŋkkat:https://doi.org/10.1172/jci.insight.171275
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