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NETUPITANT, A POTENT AND HIGHLY SELECTIVE NK1 RECEPTOR ANTAGONIST, ALLEVIATES ACETIC ACID-INDUCED BLADDER OVERACTIVITY IN ANESTHETIZED GUINEA-PIGS

Introduction. Tachykinins potently contract the isolated urinary bladder from a number of animal species and play an important role in the regulation of the micturition reflex. On the guinea-pig isolated urinary bladder we examined the effects of a new potent and selective NK1 receptor antagonist (n...

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Principais autores: Stefano Palea, Veronique Guilloteau, Moez Rekik, Emanuela Lovati, Marc Guerard, Maria-Alba Guardia, Philippe Lluel, Claudio Pietra, Mitsuharu Yoshiyama
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016-08-01
Colecção:Frontiers in Pharmacology
Assuntos:
Acetic Acid
Substance P
Tachykinins
Detrusor muscle
Netupitant
cystometry
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00234/full
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