Next-generation sequencing of BRCA1 and BRCA2 genes for rapid detection of germline mutations in hereditary breast/ovarian cancer

Background Conventional methods used to identify BRCA1 and BRCA2 germline mutations in hereditary cancers, such as Sanger sequencing/multiplex ligation-dependent probe amplification (MLPA), are time-consuming and expensive, due to the large size of the genes. The recent introduction of next-generati...

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Главные авторы:	Arianna Nicolussi, Francesca Belardinilli, Yasaman Mahdavian, Valeria Colicchia, Sonia D’Inzeo, Marialaura Petroni, Massimo Zani, Sergio Ferraro, Virginia Valentini, Laura Ottini, Giuseppe Giannini, Carlo Capalbo, Anna Coppa
Формат:	Artigo
Язык:	Inglês
Опубликовано:	PeerJ Inc. 2019-04-01
Серии:	PeerJ
Предметы:	Next-generation sequencing Hereditary breast/ovarian cancer DNA testing BRCA1 BRCA2
Online-ссылка:	https://peerj.com/articles/6661.pdf
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