Role of lung ornithine aminotransferase in idiopathic pulmonary fibrosis: regulation of mitochondrial ROS generation and TGF-β1 activity

Abstract Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant lung remodeling and the excessive accumulation of extracellular matrix (ECM) proteins. In a previous study, we found that the levels of ornithine aminotransferase (OAT), a principal enzyme in the proline metabolism pathway, we...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Jong-Uk Lee, Ki Sung Song, Jisu Hong, Hyesun Shin, Eunji Park, Junyeong Baek, Shinhee Park, Ae-Rin Baek, Junehyuk Lee, An Soo Jang, Do Jin Kim, Su Sie Chin, U-Jin Kim, Sung Hwan Jeong, Sung-Woo Park
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Publishing Group 2024-02-01
Цуврал:	Experimental and Molecular Medicine
Онлайн хандалт:	https://doi.org/10.1038/s12276-024-01170-w
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!