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GLYCATION IN DEMETALATED SUPEROXIDE DISMUTASE 1 PREVENTS AMYLOID AGGREGATION AND PRODUCES CYTOTOXIC AGEs ADDUCTS

Superoxide dismutase 1 (SOD1) has been implicated with familial amyotrophic lateral sclerosis (fALS) through accumulation of protein amyloid aggregates in motor neurons of patients. Amyloid aggregates and protein inclusions are a common pathological feature of many neurological disorders in which pr...

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Main Authors: Ivana Sirangelo, Filomena Monica Vella, Gaetano Irace, Giuseppe Manco, Clara Iannuzzi
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
Cytotoxicity
ages
SOD1
amyloid aggregation
Protein glycation
Fals
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmolb.2016.00055/full
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