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Decoding CTCs in osteosarcoma: the molecular journey from initial tumor to metastasis

Abstract Metastatic relapse remains the main cause of treatment failure in pediatric osteosarcoma (OS), as conventional imaging often misses minimal residual or low-burden disease. Circulating tumor cells (CTCs) represent a promising non-invasive biomarker for monitoring tumor progression and hetero...

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Principais autores: Alessandro Di Gangi, Mariangela Morelli, Edoardo Ipponi, Fabrizio Catena, Luca Coccoli, Raffaele Gaeta, Paolo Aretini, Michele Menicagli, Alessandro Franchi, Gaia Palmini, Gabriella Casazza, Lorenzo Andreani, Teresa Iantomasi, Maria Luisa Brandi, Chiara Maria Mazzanti, Francesca Lessi
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2026-04-01
Series:Scientific Reports
Assuntos:
Circulating tumor cells
Osteosarcoma
Liquid biopsy
Copy number alterations
Mesenchymal-to-epithelial transition
Whole-exome sequencing
Acceso en liña:https://doi.org/10.1038/s41598-026-47094-5
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