IQSEC2 Deficiency Results in Abnormal Social Behaviors Relevant to Autism by Affecting Functions of Neural Circuits in the Medial Prefrontal Cortex

IQSEC2 is a guanine nucleotide exchange factor (GEF) for ADP-ribosylation factor 6 (Arf6), of which protein is exclusively localized to the postsynaptic density of the excitatory synapse. Human genome studies have revealed that the IQSEC2 gene is associated with X-linked neurodevelopmental disorders...

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Bibliografische Detailangaben

Hauptverfasser:	Anuradha Mehta, Yoshinori Shirai, Emi Kouyama-Suzuki, Mengyun Zhou, Takahiro Yoshizawa, Toru Yanagawa, Takuma Mori, Katsuhiko Tabuchi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-10-01
Schriftenreihe:	Cells
Schlagworte:	IQSEC2 medial prefrontal cortex (mPFC) social behavior autism synapse
Online-Zugang:	https://www.mdpi.com/2073-4409/10/10/2724
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