Mathematical Modeling of Complement Pathway Dynamics for Target Validation and Selection of Drug Modalities for Complement Therapies

Motivation: The complement pathway plays a critical role in innate immune defense against infections. Dysregulation between activation and regulation of the complement pathway is widely known to contribute to several diseases. Nevertheless, very few drugs that target complement proteins have made it...

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Bibliografiska uppgifter

Huvudupphov:	Loveleena Bansal, Eva-Maria Nichols, Daniel P. Howsmon, Jessica Neisen, Christina M. Bessant, Fraser Cunningham, Sebastien Petit-Frere, Steve Ludbrook, Valeriu Damian
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Frontiers Media S.A. 2022-04-01
Serie:	Frontiers in Pharmacology
Ämnen:	complement pathway mathematical modeling Quantitative Systems Pharmacology drug modality selection target validation dose prediction
Länkar:	https://www.frontiersin.org/articles/10.3389/fphar.2022.855743/full
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