Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity

Disease-mediated alterations to drug disposition constitute a significant source of adverse drug reactions. Cisplatin (CDDP) elicits nephrotoxicity due to exposure in proximal tubule cells during renal secretion. Alterations to renal drug transporter expression have been discovered during nonalcohol...

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Detalles Bibliográficos

Principais autores:	Joseph L. Jilek, Kayla L. Frost, Kevyn A. Jacobus, Wenxi He, Erica L. Toth, Michael Goedken, Nathan J. Cherrington
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2021-12-01
Series:	Acta Pharmaceutica Sinica B
Assuntos:	Nonalcoholic steatohepatitis NASH Cisplatin Drug transporter Nephrotoxicity
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2211383521002100
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