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Exploring the Inhibition of Quercetin on Acetylcholinesterase by Multispectroscopic and In Silico Approaches and Evaluation of Its Neuroprotective Effects on PC12 Cells

This study investigated the inhibitory mechanism of quercetin in acetylcholinesterase (AChE) and its neuroprotective effects on β-amyloid<sub>25–35</sub>-induced oxidative stress injury in PC12 cells. Quercetin inhibited AChE in a reversible mixed manner with an IC<sub>50</sub> of 4.59 ± 0.27 µM. Th...

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Principais autores: Yijing Liao, Xi Mai, Xiaqing Wu, Xing Hu, Xiaoqiao Luo, Guowen Zhang
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2022-11-01
Series:Molecules
Assuntos:
acetylcholinesterase
quercetin
inhibitory mechanism
computational docking
oxidative stress
Acceso en liña:https://www.mdpi.com/1420-3049/27/22/7971
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