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An orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour

Abstract Cortical layer 6 neurons are the only projection neuron population in the cortical mantle known to electrophysiologically respond to orexin—a neuropeptide involved in cortical arousal and emotive behaviour. These neurons exhibit extensive intercortical and thalamic projections, yet the exac...

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Principais autores: Fernando Messore, Rajeevan Narayanan Therpurakal, Jean-Philippe Dufour, Anna Hoerder-Suabedissen, Luiz Guidi, Kim Korrell, Marissa Mueller, Mohammed Abuelem, Armin Lak, David M. Bannerman, Edward O. Mann, Zoltán Molnár
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2025-04-01
Serija:Translational Psychiatry
Online dostop:https://doi.org/10.1038/s41398-025-03350-2
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