Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life

Summary: Monoclonal IgG antibodies are the fastest growing class of biologics, but large differences exist in their plasma half-life in humans. Thus, to design IgG antibodies with favorable pharmacokinetics, it is crucial to identify the determinants of such differences. Here, we demonstrate that th...

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Bibliografiske detaljer

Principais autores:	Algirdas Grevys, Rahel Frick, Simone Mester, Karine Flem-Karlsen, Jeannette Nilsen, Stian Foss, Kine Marita Knudsen Sand, Thomas Emrich, Jens Andre Alexander Fischer, Victor Greiff, Inger Sandlie, Tilman Schlothauer, Jan Terje Andersen
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2022-02-01
Serier:	iScience
Fag:	Biological sciences Immunology Biophysics
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2589004222000165
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