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The cytosolic chaperonin CCT/TRiC and cancer cell proliferation.

The molecular chaperone CCT/TRiC plays a central role in maintaining cellular proteostasis as it mediates the folding of the major cytoskeletal proteins tubulins and actins. CCT/TRiC is also involved in the oncoprotein cyclin E, the Von Hippel-Lindau tumour suppressor protein, cyclin B and p21(ras)...

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Principais autores: Chafika Boudiaf-Benmammar, Thierry Cresteil, Ronald Melki
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Acceso en liña:http://europepmc.org/articles/PMC3628893?pdf=render
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