Mismatch repair deficiency testing in Lynch syndrome-associated urothelial tumors

IntroductionLynch syndrome-associated cancer develops due to germline pathogenic variants in one of the mismatch repair (MMR) genes, MLH1, MSH2, MSH6 or PMS2. Somatic second hits in tumors cause MMR deficiency, testing for which is used to screen for Lynch syndrome in colorectal cancer and to guide...

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Detalles Bibliográficos

Principais autores:	Maria Rasmussen, Peter Sowter, Richard Gallon, Jon Ambæk Durhuus, Christine Hayes, Ove Andersen, Mef Nilbert, Lone Schejbel, Estrid Høgdall, Mauro Santibanez-Koref, Michael S. Jackson, John Burn, Christina Therkildsen
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2023-04-01
Series:	Frontiers in Oncology
Assuntos:	Lynch syndrome urothelial cancer universal testing mismatch repair deficiency immunohistochemistry microsatellite instability
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1147591/full
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