Repurposing Drugs for Inhibition against ALDH2 via a 2D/3D Ligand-Based Similarity Search and Molecular Simulation

Aldehyde dehydrogenase-2 (ALDH2) is a crucial enzyme participating in intracellular aldehyde metabolism and is acknowledged as a potential therapeutic target for the treatment of alcohol use disorder and other addictive behaviors. Using previously reported ALDH2 inhibitors of Daidzin, CVT-10216, and...

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Auteurs principaux:	Wanyun Jiang, Junzhao Chen, Puyu Zhang, Nannan Zheng, Le Ma, Yongguang Zhang, Haiyang Zhang
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2023-10-01
Collection:	Molecules
Sujets:	drug repurposing ligand-based virtual screening substance use disorder receptor–ligand interactions
Accès en ligne:	https://www.mdpi.com/1420-3049/28/21/7325
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