Activation of Interferon Signaling in Chronic Lymphocytic Leukemia Cells Contributes to Apoptosis Resistance via a JAK-Src/STAT3/Mcl-1 Signaling Pathway

Besides their antiviral and immunomodulatory functions, type I (α/β) and II (γ) interferons (IFNs) exhibit either beneficial or detrimental effects on tumor progression. Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of abnormal CD5⁺ B lymphocytes that escape deat...

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Hlavní autoři:	Brigitte Bauvois, Elodie Pramil, Ludovic Jondreville, Claire Quiney, Florence Nguyen-Khac, Santos A. Susin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2021-02-01
Edice:	Biomedicines
Témata:	apoptosis CLL IFN signaling Mcl-1 STAT3 survival
On-line přístup:	https://www.mdpi.com/2227-9059/9/2/188
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