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Regulation of Tumor Metabolism and Extracellular Acidosis by the TIMP-10–CD63 Axis in Breast Carcinoma

A hallmark of malignant solid tumor is extracellular acidification coupled with metabolic switch to aerobic glycolysis. Using the human MCF10A progression model of breast cancer, we show that glycolytic switch and extracellular acidosis in aggressive cancer cells correlate with increased expression...

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Principais autores: Abdo J. Najy, Young-Suk Jung, Seongho Kim, Rafael Fridman, Hyeong-Reh C. Kim
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-10-01
Serier:Cells
Fag:
TIMP-1
CD-63
acidosis
CAIX
tumor metabolism
Online adgang:https://www.mdpi.com/2073-4409/10/10/2721
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