Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice

Abstract Calcineurin (Cn), a phosphatase important for synaptic plasticity and neuronal development, has been implicated in the etiology and pathophysiology of neuropsychiatric disorders, including schizophrenia, intellectual disability, autism spectrum disorders, epilepsy, and Alzheimer’s disease....

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Principais autores:	Hideo Hagihara, Hirotaka Shoji, Mahomi Kuroiwa, Isabella A. Graef, Gerald R. Crabtree, Akinori Nishi, Tsuyoshi Miyakawa
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-11-01
coleção:	Molecular Brain
Assuntos:	Calcineurin Immature dentate gyrus Dopamine receptor cAMP Intellectual disability Mouse model
Acesso em linha:	https://doi.org/10.1186/s13041-022-00981-0
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