Novel Ex Vivo Zymography Approach for Assessment of Protease Activity in Tissues with Activatable Antibodies

Proteases are involved in the control of numerous physiological processes, and their dysregulation has been identified in a wide range of pathologies, including cancer. Protease activity is normally tightly regulated post-translationally and therefore cannot be accurately estimated based on mRNA or...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Bruce Howng, Michael B. Winter, Carol LePage, Irina Popova, Michael Krimm, Olga Vasiljeva
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-09-01
Schriftenreihe:	Pharmaceutics
Schlagworte:	protease activity in situ zymography Probody therapeutics diagnostic therapeutic cancer
Online-Zugang:	https://www.mdpi.com/1999-4923/13/9/1390
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