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Studies toward the Total Synthesis of Itralamide B and Biological Evaluation of Its Structural Analogs

Itralamides A and B were isolated from the lipophilic extract of Lyngbya majuscula collected from the eastern Caribbean. Itralamide B (1) showed cytotoxic activity towards human embryonic kidney cells (HEK293, IC50 = 6 μM). Preliminary studies disapproved the proposed stereochemistry of itralamide....

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Principais autores: Xiaoji Wang, Chanshan Lv, Junmin Feng, Linjun Tang, Zhuo Wang, Yuqing Liu, Yi Meng, Tao Ye, Zhengshuang Xu
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2015-04-01
Serier:Marine Drugs
Fag:
itralamide B
cyclodepsipeptide
total synthesis
structural analogs
biological study
Online adgang:http://www.mdpi.com/1660-3397/13/4/2085
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