Enhancing Oral Bioavailability of Simvastatin Using Uncoated and Polymer-Coated Solid Lipid Nanoparticles

Simvastatin (SVA) is a well-prescribed drug for treating cardiovascular and hypercholesterolemia. Due to the extensive hepatic first-pass metabolism and poor solubility, its oral bioavailability is 5%. Solid lipid nanoparticles (SLNs) and hydrogel-coated SLNs were investigated to overcome the limite...

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Detalhes bibliográficos

Principais autores:	Amira E. Abd-Elghany, Omar El-Garhy, Adel Al Fatease, Ali H. Alamri, Hamdy Abdelkader
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-06-01
coleção:	Pharmaceutics
Assuntos:	solid lipid nanoparticles polymeric coating Precirol ATO 5 Compritol 888 ATO chitosan simvastatin
Acesso em linha:	https://www.mdpi.com/1999-4923/16/6/763
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