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Development of a hypoxia-responsive macrophage prognostic model using single-cell and bulk RNA sequencing in pancreatic cancer.

<h4>Objective</h4>Pancreatic ductal adenocarcinoma (PDAC) is characterized by a low survival rate and limited responsiveness to current therapies. The role of hypoxia in the tumor microenvironment is critical, influencing tumor progression and therapy resistance. The aim of this study was to impleme...

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Autors principals: Heming Ge, Gerrit Wolters-Eisfeld, Thilo Hackert, Yuqiang Li, Cenap Güngör
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2025-01-01
Col·lecció:PLoS ONE
Accés en línia:https://doi.org/10.1371/journal.pone.0322618
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