The Light Chain Defines the Duration of Action of Botulinum Toxin Serotype A Subtypes
ABSTRACT Botulinum neurotoxin (BoNT) is the causative agent of botulism and a widely used pharmaceutical to treat a variety of neurological diseases. BoNTs are 150-kDa protein toxins organized into heavy chain (HC) and light chain (LC) domains linked by a disulfide bond. The HC selectively binds to...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
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American Society for Microbiology
2018-05-01
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| Serie: | mBio |
| Soggetti: | |
| Accesso online: | https://journals.asm.org/doi/10.1128/mBio.00089-18 |
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