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Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice

Abstract We previously showed that Irisin, a myokine released from skeletal muscle after physical exercise, plays a central role in the control of bone mass. Here we report that treatment with recombinant Irisin prevented bone loss in hind-limb suspended mice when administered during suspension (pre...

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Hoofdauteurs: Graziana Colaianni, Teresa Mongelli, Concetta Cuscito, Paolo Pignataro, Luciana Lippo, Giovanna Spiro, Angela Notarnicola, Ilenia Severi, Giovanni Passeri, Giorgio Mori, Giacomina Brunetti, Biagio Moretti, Umberto Tarantino, Silvia C. Colucci, Janne E. Reseland, Roberto Vettor, Saverio Cinti, Maria Grano
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Portfolio 2017-06-01
Reeks:Scientific Reports
Online toegang:https://doi.org/10.1038/s41598-017-02557-8
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