Epigenetic and metabolic reprogramming in autoimmune rheumatology: toward immune tolerance reprogramming

Autoimmune rheumatic diseases arise when the immune system transitions from a flexible, self-regulating network into a metabolically and epigenetically fixed inflammatory attractor state. This review synthesizes emerging evidence that immune tolerance is governed by a coupled epigenetic-metabolic ax...

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Autors principals:	Ola A Al-Ewaidat, Moawiah M Naffaa
Format:	Artigo
Idioma:	Inglês
Publicat:	Open Exploration Publishing Inc. 2026-05-01
Col·lecció:	Exploration of Immunology
Matèries:	immune tolerance reprogramming epigenetic remodeling immunometabolism autoimmune rheumatic diseases chromatin-metabolism coupling mitochondrial dysfunction regulatory t cells precision immunomodulation
Accés en línia:	https://www.explorationpub.com/uploads/Article/A1003255/1003255.pdf
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