MDMA, methamphetamine, and CYP2D6 pharmacogenetics: what is clinically relevant?

In vitro human studies show that the metabolism of most amphetamine-like psychostimulants is regulated by the polymorphic cytochrome P450 isozyme CYP2D6. Two compounds, methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA), were selected as archetypes to discuss the translation and clinical s...

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Autors principals:	Rafael eDe La Torre, Samanta eYubero-Lahoz, Ricardo ePardo-Lozano, Magi eFarre
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2012-11-01
Col·lecció:	Frontiers in Genetics
Matèries:	Methamphetamine Pharmacogenetics CYP2D6 MDMA ecstasy
Accés en línia:	http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00235/full
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