Prion-derived tetrapeptide stabilizes thermolabile insulin via conformational trapping

Summary: Unfolding followed by fibrillation of insulin even in the presence of various excipients grappled with restricted clinical application. Thus, there is an unmet need for better thermostable, nontoxic molecules to preserve bioactive insulin under varying physiochemical perturbations. In searc...

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主要な著者:	Meghomukta Mukherjee, Debajyoti Das, Jit Sarkar, Nilanjan Banerjee, Jagannath Jana, Jyotsna Bhat, Jithender Reddy G, Jagadeesh Bharatam, Samit Chattopadhyay, Subhrangsu Chatterjee, Partha Chakrabarti
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2021-06-01
シリーズ:	iScience
主題:	Medical biochemistry Molecular physiology Biomolecular engineering Structural biology
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2589004221005411
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