Late clinical failure associated with cytochrome b codon 268 mutation during treatment of falciparum malaria with atovaquone–proguanil in traveller returning from Congo

Abstract Background The drug combination atovaquone–proguanil, is recommended for treatment of uncomplicated falciparum malaria in France. Despite high efficacy, atovaquone–proguanil treatment failures have been reported. Resistance to cycloguanil, the active metabolite of proguanil, is conferred by...

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Detalhes bibliográficos

Principais autores:	Laurencie Massamba, Marylin Madamet, Nicolas Benoit, Alicia Chevalier, Isabelle Fonta, Véronique Mondain, Pierre-Yves Jeandel, Rémy Amalvict, Pascal Delaunay, Joel Mosnier, Pierre Marty, Christelle Pomares, Bruno Pradines
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-01-01
coleção:	Malaria Journal
Assuntos:	Malaria Plasmodium falciparum Anti-malarial drug Resistance In vitro Atovaquone
Acesso em linha:	https://doi.org/10.1186/s12936-020-3126-y
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