Shared and distinct mechanisms of UBA1 inactivation across different diseases

Abstract Most cellular ubiquitin signaling is initiated by UBA1, which activates and transfers ubiquitin to tens of E2 enzymes. Clonally acquired UBA1 missense mutations cause an inflammatory-hematologic overlap disease called VEXAS (vacuoles, E1, X-linked, autoinflammatory, somatic) syndrome. Despi...

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Principais autores:	Jason C Collins, Samuel J Magaziner, Maya English, Bakar Hassan, Xiang Chen, Nicholas Balanda, Meghan Anderson, Athena Lam, Sebastian Fernandez-Pol, Bernice Kwong, Peter L Greenberg, Benjamin Terrier, Mary E Likhite, Olivier Kosmider, Yan Wang, Nadine L Samara, Kylie J Walters, David B Beck, Achim Werner
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Springer Nature 2024-02-01
סדרה:	The EMBO Journal
נושאים:	UBA1 Ubiquitin VEXAS Syndrome Spinal Muscular Atrophy (SMA) Lung Cancer in Never Smokers (LCINS)
גישה מקוונת:	https://doi.org/10.1038/s44318-024-00046-z
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