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Response to crizotinib treatment for ROS1 p.H1999N mutation and secondary EGFR p.V774M mutation after drug resistance: a Case Report

Genetic fusion involving the ROS1 gene lead to the constitutive activation of its encoded tyrosine kinase, thereby acting as an oncogenic driver that promotes tumor cell proliferation. Numerous missense mutations in ROS1 are currently classified as variants of unknown significance, especially, mutat...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Yalin He, Yuan Tang, Ruixuan Yu, Yongmei Liu
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2026-05-01
Rangatū:Frontiers in Pharmacology
Ngā marau:
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fphar.2026.1777570/full
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