In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo

The role of brain-derived neurotrophic factor (BDNF) signaling in chronic pain has been well documented. Given the important central role of BDNF in long term plasticity and memory, we sought to engineer a high affinity, peripherally-restricted monoclonal antibody against BDNF to modulate pain. BDNF...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Edwina Stack, Sheridan McMurray, Gordon McMurray, Jason Wade, Melissa Clark, Gareth Young, Kim Marquette, Sadhana Jain, Kerry Kelleher, Ting Chen, Qingcong Lin, Laird Bloom, Laura Lin, William Finlay, Rie Suzuki, Orla Cunningham
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Taylor & Francis Group 2020-01-01
Rangatū:	mAbs
Ngā marau:	BDNF chronic pain monoclonal antibody chickens affinity optimization peripheral nerve injury
Urunga tuihono:	https://www.tandfonline.com/doi/10.1080/19420862.2020.1755000
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!