Triple-tracer PET (18F-FDG, 68Ga-DOTANOC, 68Ga-FAPI) maps inter- and intra-lesional heterogeneity in metastatic high-grade neuroendocrine neoplasms

Abstract This pilot study evaluated the diagnostic performance of a triple-tracer PET/CT protocol in 13 patients with advanced, high-grade neuroendocrine neoplasms (NENs; Ki-67 > 40%). NENs are characterized by biological heterogeneity and variable tracer avidity, complicating accurate staging and t...

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Hlavní autoři:	Prathap Jayachandra Hosahalli, S. P. Somashekar, D. N. Bhoomika, B. R. Abhijit, Vishwanath Joshi, Prashanth Ramachandra Guthlu, Rajkumar Krishnappa, Mita Kumarswamy Kallur, Palak Wadhwa, K. R. Ashwin, C. Rohit Kumar, Sai Vivek, Suva Lakshmi, Prajwal Rajaghatta Kumaraswamy, B. Shameer Ahmed
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-05-01
Edice:	Scientific Reports
Témata:	Neuroendocrine neoplasms FDG PET/CT DOTANOC FAPI Tumor heterogeneity Stroma
On-line přístup:	https://doi.org/10.1038/s41598-026-51131-8
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