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The efficacy of atezolizumab plus bevacizumab for advanced hepatocellular carcinoma in relation to tumor-infiltrating lymphocytes

Background & Aims: Atezolizumab plus bevacizumab (Atez/Bev) improves prognosis in advanced hepatocellular carcinoma, but its mechanisms remain unclear. This study aims to identify predictive biomarkers through a comprehensive analysis of the tumor microenvironment. Methods: Biopsy samples from 9...

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Principais autores: Hiroaki Kanzaki, Takamasa Ishino, Sadahisa Ogasawara, Takahiro Tsuchiya, Makoto Fujiya, Midori Sawada, Ryo Izai, Teppei Akatsuka, Chihiro Miwa, Takuya Yonemoto, Sae Yumita, Miyuki Nakagawa, Ryuta Kojima, Keisuke Koroki, Masanori Inoue, Kazufumi Kobayashi, Naoya Kanogawa, Masato Nakamura, Takayuki Kondo, Shingo Nakamoto, Tsukasa Takayashiki, Yuka Takano, Kaho Takata, Jason Lin, Masahito Kawazu, Jun-ichiro Ikeda, Masayuki Ohtsuka, Yujin Hoshida, Mina Komuta, Yosuke Togashi
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-12-01
Serier:JHEP Reports
Fag:
atezolizumab
bevacizumab
immunotherapy
hepatocellular carcinoma
tumor-infiltrating lymphocyte
tumor microenvironment
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589555925002964
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