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Action of Clathrodin and Analogues on Voltage-Gated Sodium Channels

Clathrodin is a marine alkaloid and believed to be a modulator of voltage-gated sodium (NaV) channels. Since there is an urgent need for small molecule NaV channel ligands as novel therapeutics, clathrodin could represent an interesting lead compound. Therefore, clathrodin was reinvestigated for its...

Celý popis

Uloženo v:
Hlavní autoři: Steve Peigneur, Aleš Žula, Nace Zidar, Fiona Chan-Porter, Robert Kirby, David Madge, Janez Ilaš, Danijel Kikelj, Jan Tytgat
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2014-04-01
Edice:Marine Drugs
Témata:
clathrodin
oroidin
hymenidin
voltage-gated sodium channels
sodium channel modulator
sponge
On-line přístup:http://www.mdpi.com/1660-3397/12/4/2132
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