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IRE1 Alpha/XBP1 Axis Sustains Primary Effusion Lymphoma Cell Survival by Promoting Cytokine Release and STAT3 Activation

Primary Effusion Lymphoma (PEL) is a highly aggressive B cell lymphoma associated with Kaposi’s Sarcoma-associated Herpesvirus (KSHV). It is characterized by a high level of basal Endoplasmic Reticulum (ER) stress, Unfolded Protein Response (UPR) activation and constitutive phosphorylation of oncoge...

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Principais autores: Roberta Gonnella, Maria Saveria Gilardini Montani, Luisa Guttieri, Maria Anele Romeo, Roberta Santarelli, Mara Cirone
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-01-01
Serier:Biomedicines
Fag:
ER stress
UPR
IRE1 alpha
XBP1
STAT3
cytokines
Online adgang:https://www.mdpi.com/2227-9059/9/2/118
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