Cilia-related gene signature in the nasal mucosa correlates with disease severity and outcomes in critical respiratory syncytial virus bronchiolitis

BackgroundRespiratory syncytial virus (RSV) can cause life-threatening respiratory failure in infants. We sought to characterize the local host response to RSV infection in the nasal mucosa of infants with critical bronchiolitis and to identify early admission gene signatures associated with clinica...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Clarissa M. Koch, Andrew D. Prigge, Leah Setar, Kishore R. Anekalla, Hahn Chi Do-Umehara, Hiam Abdala-Valencia, Yuliya Politanska, Avani Shukla, Jairo Chavez, Grant R. Hahn, Bria M. Coates
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2022-09-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	RSV nasal mucosa RNA-Seq bronchiolitis pediatric critical care
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.924792/full
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