Leptin antagonism improves Rett syndrome phenotype in symptomatic Mecp2-deficient mice
Rett syndrome (RTT) is a severe X-linked neurodevelopmental disorder caused by mutations in MECP2. Elevated circulating levels of the adipocyte hormone leptin are consistently observed in patients and in mouse models, yet their contribution to disease progression has remained unclear. Here, we show...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2026-04-01
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| Serie: | Neurotherapeutics |
| Soggetti: | |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S1878747926000802 |
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