Ultrasound-induced mechanical damage of cancer cell cytoskeleton causes disruption of nuclear envelope and activation of cGAS-STING

Abstract Neoplastic transformation is accompanied by critical changes in cell mechanical properties, including reduced cell elasticity. By leveraging such mechanical flaw, exposure to low intensity therapeutic ultrasounds (LITUS) has been proposed as a tool for selective killing of cancer cells. Her...

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Principais autores:	Giorgia Federico, Angelo Rosario Carotenuto, Arsenio Cutolo, Stefania Palumbo, Marialuisa Moccia, Simona Paladino, Massimo Santoro, Tommaso Russo, Massimiliano Fraldi, Francesca Carlomagno
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2025-05-01
Serija:	Scientific Reports
Teme:	LITUS Prostate cancer LINC DNA damage cGAS-STING Cell mechanics
Online dostop:	https://doi.org/10.1038/s41598-025-03317-9
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