Replication/Assembly Defective Avian Flavivirus With Internal Deletions in the Capsid Can Be Used as an Approach for Living Attenuated Vaccine

Avian Tembusu virus (TMUV) is a novel flavivirus causing severe egg drop and fatal encephalitis in avian in Asia. In the present study, we screened the structural and functional requirements of TMUV capsid protein (CP) for viral morphogenesis using reverse genetics methods in combination with replic...

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Автори:	Yu He, Xiaoli Wang, Jiaqi Guo, Li Mao, Senzhao Zhang, Tao Hu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Sai Mao, Xumin Ou, Qun Gao, Di Sun, Yunya Liu, Ling Zhang, Yanling Yu, Anchun Cheng, Shun Chen
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2021-08-01
Серія:	Frontiers in Immunology
Предмети:	live attenuated vaccine assembly deficient avian Tembusu virus capsid protein deletion protective immunity immune response
Онлайн доступ:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.694959/full
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