JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression

Abstract Background Prostate cancer develops through malignant transformation of the prostate epithelium in a stepwise, mutation-driven process. Although activator protein-1 transcription factors such as JUN have been implicated as potential oncogenic drivers, the molecular programs contributing to...

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Autores principales:	Torben Redmer, Martin Raigel, Christina Sternberg, Roman Ziegler, Clara Probst, Desiree Lindner, Astrid Aufinger, Tanja Limberger, Karolina Trachtova, Petra Kodajova, Sandra Högler, Michaela Schlederer, Stefan Stoiber, Monika Oberhuber, Marco Bolis, Heidi A. Neubauer, Sara Miranda, Martina Tomberger, Nora S. Harbusch, Ines Garces de los Fayos Alonso, Felix Sternberg, Richard Moriggl, Jean-Philippe Theurillat, Boris Tichy, Vojtech Bystry, Jenny L. Persson, Stephan Mathas, Fritz Aberger, Birgit Strobl, Sarka Pospisilova, Olaf Merkel, Gerda Egger, Sabine Lagger, Lukas Kenner
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2024-05-01
Colección:	Molecular Cancer
Materias:	Prostate cancer AP-1 transcription factors JUN Senescence SASP Immune infiltration
Acceso en línea:	https://doi.org/10.1186/s12943-024-02022-x
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