Alternative promoters and splicing create multiple functionally distinct isoforms of oestrogen receptor alpha in breast cancer and healthy tissues

Abstract Background Oestrogen receptor alpha (ER) is involved in cell growth and proliferation and functions as a transcription factor, a transcriptional coregulator, and in cytoplasmic signalling. It affects, for example, bone, endometrium, ovaries and mammary epithelium. It is a key biomarker in c...

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Hlavní autoři:	Carlos Enrique Balcazar Lopez, Juliane Albrecht, Völundur Hafstað, Cornelia Börjesson Freitag, Johan Vallon‐Christersson, Cristian Bellodi, Helena Persson
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2023-09-01
Edice:	Cancer Medicine
Témata:	alternative splicing breast cancer isoforms oestrogen receptor
On-line přístup:	https://doi.org/10.1002/cam4.6508
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