Regional brain mGlu5 receptor occupancy following single oral doses of mavoglurant as measured by [11C]-ABP688 PET imaging in healthy volunteers

Mavoglurant binds to same allosteric site on metabotropic glutamate receptor 5 (mGluR5) as [11C]-ABP688, a radioligand. This open-label, single-center pilot study estimates extent of occupancy of mGluR5 receptors following single oral doses of mavoglurant, using [11C]-ABP688 positron emission tomogr...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Johannes Streffer, Valerie Treyer, Alfred Buck, Simon M. Ametamey, Milen Blagoev, Ralph P Maguire, Aurélie Gautier, Yves P. Auberson, Mark E. Schmidt, Ivan-Toma Vranesic, Baltazar Gomez-Mancilla, Fabrizio Gasparini
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Elsevier 2021-04-01
Sarja:	NeuroImage
Aiheet:	Mavoglurant mGluR5 PET imaging Receptor occupancy Single oral dose
Linkit:	http://www.sciencedirect.com/science/article/pii/S1053811921000628
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