Enhanced disulphide bond stability contributes to the once-weekly profile of insulin icodec
Abstract Insulin icodec is a once-weekly insulin analogue that has a long half-life of approximately 7 days, making it suitable for once weekly dosing. The Insulin icodec molecule was developed based on the hypothesis that lowering insulin receptor affinity and introducing a strong albumin-binding m...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Portfolio
2024-07-01
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| Серии: | Nature Communications |
| Online-ссылка: | https://doi.org/10.1038/s41467-024-50477-9 |
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