Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway

Abstract Background Pathogenic or null mutations in WRN helicase is a cause of premature aging disease Werner syndrome (WS). WRN is known to protect somatic cells including adult stem cells from premature senescence. Loss of WRN in mesenchymal stem cells (MSCs) not only drives the cells to premature...

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Autores principales:	Hei-Yin Tam, Jiaxing Liu, Tsz-Ching Yiu, Adrian On-Wah Leung, Chang Li, Shen Gu, Owen Rennert, Boxian Huang, Hoi-Hung Cheung
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-01-01
Colección:	Cell & Bioscience
Materias:	Werner syndrome AKT signaling SHIP Senescence WRN Mesenchymal stem cell
Acceso en línea:	https://doi.org/10.1186/s13578-025-01355-4
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